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A case is reported of reversible panhypogammaglobulinemia in a human immunodeficiency virus(HIV)-infected patient.Onset and resolution were temporally correlated with initiation and termination,respectively,of diphenylhydantoin therapy for a possible seizure.A rapid alteration in peripheral T-cell subpopulations was also noted in association with diphenylhydantoin administration.This case is compared with previous reports of diphenylhydantoin-associated hypogammaglobulinemia in non-HIV- infected patients.In addition,the case is discussed with regard to possible deleterious effects associated with the use of diphenylhydantoin as therapy for HIV-associated seizures or as an antiretroviral agent in HIV disease. |
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